Two to Tango : Pneumococcal Infection to the Human Host
The Gram positive, Streptococcus pneumoniae is a commensal microbiota living in the human nasopharyngeal passage, the area of upper throat behind the nose. From this colonization site, the pneumococcus can spread elsewhere in the human body: to the lung to cause pneumoniae, to the blood, causing septicemia and to the meninges, causing meningitis. In this sites of colonization and infection, the bacteria encounters different (micro)niches, including various carbon and nitrogenous sources, inflammation and immunity factors and diverse human cell-types.
In the study, we ask ourselves how both the pneumococcus and human cells adapt and behave during these interspecies encounters.