Rieza Aprianto

Two to Tango : Pneumococcal Infection to the Human Host

 

Rieza Aprianto

The Gram positive, Streptococcus pneumoniae is a commensal microbiota living in the human nasopharyngeal passage, the area of upper throat behind the nose. From this colonization site, the pneumococcus can spread elsewhere in the human body: to the lung to cause pneumoniae, to the blood, causing septicemia and to the meninges, causing meningitis. In this sites of colonization and infection, the bacteria encounters different (micro)niches, including various carbon and nitrogenous sources, inflammation and immunity factors and diverse human cell-types. 

In the study, we ask ourselves how both the pneumococcus and human cells adapt and behave during these interspecies encounters.

Colonization
Progression of Streptococcus pneumoniae colonization and infection in the human host. 
Multiple niches are encountered; lethality may arise after pneumococcal pneumonia, septicemia and meningitis.

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