Peptides with intramolecular bridges.
This project, which has been made possible by Samenwerkingsverband Noord Nederland (SNN) and the Province of Groningen concerns a two year collaboration of the Molecular Genetics Department with Lanthio Pharma, a therapeutic peptide discovery company in Groningen. The project aims at eventually generating peptides with high therapeutic potential. Goal of the project is to develop the technology to enzymatically introduce larger intramolecular bridges in peptide therapeutics. This will expand the possibilities to generate therapeutics with highly specific receptor interaction and good drug-like properties due to resistance to breakdown by peptidases. In particular the technology will enable to stabilize alpha helix structures, which are important for receptor interactions.