Welcome at the home page of Molecular Genetics.
The Molecular Genetics group focuses on the molecular biology, physiology, genetics, cell biology and functional genomics of AT-rich Gram-positive bacteria of industrial and health interest.
The vision is to fully understand the molecular mechanisms underlying life and adaptation of our model bacteria to changing environments. Furthermore, we are interested in different aspects of RNA folding, RNA structure and biological function (incaRNAtolab).
Our mission is to perform top science using advanced genetics, genomics, bioinformatics and single cell analytical tools to address fundamental and applied research questions.
- Lactococcus lactis is investigated as model system for various biotechnological applications among which engineering of ribosomally synthesized and posttranslationally modified peptides (RiPPs), and for basic research on gene regulation.
- The human pathogen Streptococcus pneumonia is studied with respect to pathogenesis and virulence.
- Bacillus subtilis is studied as a potential cell factory for production of enzymes and nonribosomal peptides (NRPs) as well as for gaining basic insights in differentiation processes, like sporulation and competence development.
- Bacilli from soil are studied for plant biocontrol purposes and antimicrobial properties.
- Another human pathogen, Pseudomonas aeruginosa, is studied aiming at the elucidation of the mode of action and preclinical development of a new treatment.
- RNA structure and function are being studied.